Publications 2009

Ahmadi R., Dictus C., Hartmann C., Zürn O., Edler L., Hartmann M., Combs S.E., Herold-Mende C., Wirtz C.R., Unterberg A.: Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients. Acta Neurochir. 151 (11) 1359-1365, 2009.

Bäuerle T., Hillengass J., Fechtner K., Zechmann C., Grenacher L., Möhler T., Heiss C., Wagner-Gund B., Neben K., Kauczor H.U., Goldschmidt H., Delorme S.: Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging. Radiology 252 (2) 477-485, 2009.

Becker N., Werft W., Tödt G., Lichter P., Benner A.: penalizedSVM: a R-package for Feature Selection SVM Classification. Bioinformat. 25 (13) 1711-1712, 2009.

Calabro A., Beissbarth T., Kuner R., Stojanov M., Benner A., Asslaber M., Ploner F., Zatloukal K., Samonigg H., Poustka A., Sültmann H.: Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer. Breast Cancer Res.Treat. 116 (1) 69-77, 2009.

Edler L., Lee J.W., Mittlböck M., Niland J., Victor N.: Computational statistics within clinical research. Editorial. Comput.Statist.Data Anal. 53 (3 specical issue) 583-585, 2009.

Edler L.: EFSA Panel on Contaminants in the food chain (CONTAM): Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils. EFSA J. 7 (11) 1391(48p.), 2009.

End C., Bikker F., Renner M., Bergmann G., Lyer S., Blaich S., Hudler M., Helmke B., Gassler N., Autschbach F., Ligtenberg A.J., Benner A., Holmskov U., Schirmacher P., Nieuw Amerongen A.V., Rosenstiel P., Sina C., Franke A., Hafner M., Kioschis P., Schreiber S., Poustka A., Mollenhauer J.: DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur.J.Immunol. 39 (3) 833-842, 2009.

Felder B., Radlwimmer B., Benner A., Mincheva A., Tödt G., Beyer K.S., Schuster C., Bölte S., Schmötzer G., Klauck S.M., Poustka F., Lichter P., Poustka A.: FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome. Am.J.Med.Genet.A 149A (5) 952-959, 2009.

Geisler C., Jurlander J., Bullinger L., Sander S., Brown P., Benner A., Philip P., Döhner H., Stilgenbauer S.: Danish CLL2-Study revisited: FISH on a cohort with a 20-year follow-up confirms the validity of the hierarchical model of genomic aberrations in chronic lymphocytic leukaemia (for the Danish CLL-2 study group). Letter to the editor. Eur.J.Haematol. 83 (2) 156-158, 2009.

Gencer D., Kästle-Larralde N., Pilz L.R., Weiss A., Buchheidt D., Hochhaus A., Hofheinz R.D.: Presentation, treatment, and analysis of prognostic factors of terminally ill patients with gastrointestinal tumors. Onkol. 32 (7) 380-386, 2009.

Giordano F., Appelt J., Zucknick M., Abba M., Zeller W.J., Frühauf S., Allgayer H., Laufs S.: Cold spots in hot spots: transcription start sites of active genes are spared from HIV vector integration. AIDS 23 (18) 2535-2537, 2009.

Halatsch M.E., Löw S., Mursch K., Hielscher T., Schmidt U., Unterberg A., Vougioukas V.I., Feuerhake F.: Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory Investigation. J.Neurosurg. 111 (211) 218, 2009.

Helfrich I., Edler L., Sucker A., Thomas M., Christian S., Schadendorf D., Augustin H.G.: Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin.Cancer Res. 15 (4) 1384-1392, 2009.

Hillengass J., Zechmann C., Bäuerle T., Wagner-Gund B., Heiss C., Benner A., Ho A.D., Neben K., Hose D., Kauczor H.U., Goldschmidt H., Delorme S., Möhler T.: Dynamic contrast-enhanced magnetic resonance imaging identifies a subgroup of patients with asymptomatic monoclonal plasma cell disease and pathologic microcirculation. Clin.Cancer Res. 15 (9) 3118-3125, 2009.

Hof H., Rhein R., Haering P., Kopp-Schneider A., Debus J., Herfarth K.: 4D-CT-based target volume definition in stereotactic radiotherapy of lung tumours: Comparison with a conventional technique using individual margins. Radiother.Oncol. 93 (13) 419-423, 2009.

Hose D., Moreaux J., Meissner C., Seckinger A., Goldschmidt H., Benner A., Mahtouk K., Hillengass J., Reme T., de Vos J., Hundemer M., Condomines M., Bertsch U., Rossi J.F., Jauch A., Klein B., Möhler T.: Induction of angiogenesis by normal and malignant plasma cells. Blood 114 (1) 128-143, 2009.

Hose D., Reme T., Meissner C., Moreaux J., Seckinger A., Lewis J., Benes V., Benner A., Hundemer M., Hielscher T., Shaughnessy J.D.jr., Barlogie B., Neben K., Kramer A., Hillengass J., Bertsch U., Jauch A., de Vos J., Rossi J.F., Möhler T., Blake J., Zimmermann J., Klein B., Goldschmidt H.: Inhibition of aurora-kinases for tailored risk adapted treatment of multiple myeloma. Blood 113 (18) 4331-4340, 2009.

Manegold C., Schmid-Bindert G., Pilz L.R.: Pemetrexed for the treatment of non-small-cell lung cancer. Expert Rev.Anticanc.Ther. 9 (9) 1195-1209, 2009.

Marx-Stölting P., Adriaens E., Ahr H.J., Bremer S., Garthoff B., Gelbke H.P., Piersma A., Pellizzer C., Reuter U., Rogiers V., Schenk B., Schwengberg S., Seiler A., Spielmann H., Steemans M., Stedman D.B., Vanparys P., Vericat J.A., Verwei M., van der Water F., Weimer M., Schwarz M.: A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop. ATLA 37 (3) 313-328, 2009.

Müller P.J., Dally H., Klappenecker C.N., Edler L., Jäger B., Gerst M., Spiegelhalder B., Tüngerthal S., Fischer J.R., Drings P., Bartsch H., Risch A.: Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients (p NA). Int.J.Cancer 124 (7) 1669-1674, 2009.

Nikolova D.A., Asangani I.A., Nelson L.D., Hughes D.P., Siwak D.R., Mills G.B., Harms A., Buchholz E., Pilz L.R., Manegold C., Allgayer H.: Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity. Cancer Res. 69 (6) 2461-2470, 2009.

Oberemm A., Ahr H.J., Bannasch P., Ellinger-Ziegelbauer H., Glückmann M., Hellmann J., Ittrich C., Kopp-Schneider A., Kramer P.J., Krause E., Kröger M., Kiss E., Richter-Reichhelm H.B., Scholz G., Seemann K., Weimer M., Gundert-Remy U.: Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: Comparison of genomic and proteomic responses and anchoring to histopathological parameters. Toxicol.Appl.Pharmacol. 241 (2) 230-245, 2009.

Öhme I., Deubzer H.E., Wegener D., Pickert D., Linke J.P., Hero B., Kopp-Schneider A., Westermann F., Ulrich S.M., von Deimling A., Fischer M., Witt O.: Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin.Cancer Res. 15 (1) 91-99, 2009.

Pfister S., Remke M., Benner A., Mendrzyk F., Tödt G., Felsberg J., Wittmann A., Devens F., Gerber N.U., Joos S., Kulozik A., Reifenberger G., Rutkowski S., Wiestler O.D., Radlwimmer B., Scheurlen W., Lichter P., Korshunov A.: Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J.Clin.Oncol. 27 (10) 1627-1636, 2009.

Remke M., Pfister S., Kox C., Tödt G., Becker N., Benner A., Werft W., Breit S., Liu S., Engel F., Wittmann A., Zimmermann M., Stanulla M., Schrappe M., Ludwig W.D., Bartam C.R., Radlwimmer B., Muckenthaler M.U., Lichter P., Kulozik A.: High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-{beta} and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood 114 (5) 1053-1062, 2009.

Rengier F., Tengg-Kobligk H.v., Zechmann C.M., Grenacher L., Möhler M., Heiss C., Wagner-Gund B., Neben K., Goldschmidt H., Kauczor H.U., Delorme S.: Beyond the eye - medical applications of 3D rapid prototyping objects. Eur.Med.Imag.Rev. 1 76-80, 2009.

Schlenk R.F., Döhner K., Kneba M., Götze K., Hartmann F., del Valle F., Kirchen H., Koller E., Fischer J.T., Bullinger L., Habdank M., Späth D., Groner S., Krebs B., Kayser S., Corbacioglu A., Anhalt A., Benner A., Fröhling S., Döhner H.: Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. Haematologica 94 (1) 54-60, 2009.

Schneider K., Schwarz M., Burkholder I., Kopp-Schneider A., Edler L., Kinsner-Ovaskainen A., Hartung T., Hoffmann S.: "ToxRTool", a new tool to assess the reliability of toxicological data. Toxicol.Lett. 189 (2) 138-144, 2009.

Seckinger A., Meissner T., Moreaux J., Goldschmidt H., Fuhler G.M., Benner A., Hundemer M., Reme T., Shaughnessy J.D.jr., Barlogie B., Bertsch U., Hillengass J., Ho A.D., Pantesco V., Jauch A., DeVos J., Rossi J.F., Möhler T., Klein B., Hose D.: Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis. Oncogene 28 (44) 3866-3879, 2009.

Sorg C., Schmidt J., Büchler M.W., Edler L., Märten A.: Examination of external validity in randomized controlled trials for adjuvant treatment of pancreatic adenocarcinoma. Pancreas 38 (5) 542-550, 2009.

Thöm I., Schult-Kronefeld O., Burkholder I., Schuch G., Kastendieck H., Edler L., Wagener C., Bokemeyer C., Schumacher U., Laack E.: Expression of CEACAM-1 in pulmonary adenocarcinomas and their metastases. Anticanc.Res. 29 (1) 249-254, 2009.

Weber M.A., Krakowski-Roosen H., Schröder L., Kinscherf R., Krix M., Kopp-Schneider A., Essig M., Bachert P., Kauczor H.U., Hildebrandt W.: Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia. Acta Oncol. 48 (1) 116-124, 2009.

Weber T.F., Tetzlaff R., Rengier F., Geisbüsch P., Kopp-Schneider A., Böckler D., Eichinger M., Kauczor H.U., Tengg-Kobligk H.v.: Respiratory displacement of the thoracic aorta: physiological phenomenon with potential implications for thoracic endovascular repair. Cardiovas.Intervent.Radiol. 32 (4) 658-665, 2009.

Weber T.F., Ganten M.K., Böckler D., Geisbüsch P., Kopp-Schneider A., Kauczor H.U., Tengg-Kobligk H.v.: Assessment of thoracic aortic conformational changes by four-dimensional computed tomography angiography in patients with chronic aortic dissection type b. Eur.Radiol. 19 (1) 245-253, 2009.

Witzens-Harig M., Reiz M., Heiss C., Benner A., Hensel M., Neben K., Dreger P., Krämer A., Ho A.D.: Quality of life during maintenance therapy with the anti-CD20 antibody rituximab in patients with B cell non-Hodgkin's lymphoma: results of a prospective randomized controlled trial. Ann.Hematol. 88 (1) 51-57, 2009.

Zechmann C., Aftab K., Didinger B., Giesel F.L., Zamecnik P., Fütterer J.J., Kopp-Schneider A., Kauczor H.U., Delorme S.: Changes of prostate gland volume with and without androgen deprivation after intensity modulated radiotherapy. A follow-up study. Radiother.Oncol. 90 (3) 408-412, 2009.

Zenz T., Benner A., Dührsen U., Dürig J., Döhner H., Siffert W., Stilgenbauer S., Nückel H.: BCL2-938C>A polymorphism and disease progression in chronic lymphocytic leukemia. Leuk.Lymphoma 50 (11) 1837-1842, 2009.

Zenz T., Benner A., Stilgenbauer S.: MDM2 promotor polymorphism and disease characteristics in CLL. Leukem.Res. 34 (5) 578-579, 2009.

Zubel A., Flechtenmacher C., Edler L., Alonso A.: Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix. Gynecol.Oncol. 114 (2) 332-336, 2009.