SCIENTIFIC PROGRAM

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Sunday, October 14

11:30 - Registration and poster mounting
13:00 - Welcome: Otmar D. Wiestler
13:15 - WELCOME LECTURE (Elaine Fuchs)
              Skin stem cells in homeostasis and cancer

Session 1 - LEUKEMIC STEM CELLS AND MICROENVIRONMENT
Chair: Andreas Trumpp

14:15 - Tariq Enver
              Genetic and epigenetic sources of heterogeneity in childhood leukaemia
14:45 - Shahin Rafii
              Angiocrine factors-derived from tumorspecified vascular niche induce and maintain tumor initiating cells

15:15 - Coffee break

15:45 - Markus Müschen
              Oncogene signaling and negative feedback in leukemia
16:15 - Catriona Jamieson
              Malignant progenitor reprogramming: Biologic and therapeutic implications
16:45 - Paul Frenette
              Neural regulation of stem cell and cancer cell migration
17:15 - David Lyden
              Tumor-derived exosomes educate bone marrow progenitor cells to a pro-metastatic phenotype

17:45 - Welcome reception

Monday, October 15

09:00 - Greeting address (Philipp U. Heitz, German Academy of Sciences Leopoldina)

Session 2 - STEM CELLS OF SOLID TUMORS AND METASTASIS
Chair: Varda Rotter

09:15 - Thomas Brabletz
              EMT, microRNAs and cancer stem cells
09:45 - Michael Clarke
              Deregulation of stem cell self-renewal pathways in cancer

10:15 - Coffee break 

10:45 - Andreas Trumpp
              Circulating metastasis-initiating cells in breast cancer
11:15 - Thea Tlsty
              Cellular conversations that control malignancy
11:45 - Luis Parada
              Genetic mouse models of glioma: Translational tools for therapeutic development

12:15 - Lunch break

13:15 - Gregory Driessens (short talk)
              Defining the mode of tumor growth by clonal analysis
13:30 - Beatriz Aranda-Orgilles (short talk)
              Regulation of stem cell self-renewal, differentiation and transformation by the ubiquitin-proteasome system

13:45 - Michael Shen
              Stem cells and the origin of prostate cancer
14:15 - Owen Witte
              Stem Cells in Prostate Cancer Initiation and Progression

14:45 - POSTER SESSION

16:30 - KEYNOTE LECTURE (Philip Beachy) 
              Sonic hedgehog-expressing basal stem cells are the cell-of-origin for bladder cancer

17:30 - Meet-the-speakers dinner, DKFZ

Tuesday, October 16

Session 3 - BRAIN TUMOR STEM CELLS
Chair: Michael Platten

09:00 - Jürgen Knoblich
              Using Drosophila as a model system for tumorigenesis and cancer stem cells.
09:30 - Ana Martin-Villalba
              The role of CD95 in Tumor initiation and tumor progression
10:00 - Haikun Liu (short talk)
              Genetic dissection of self-renewal and differentiation in normal and malignant brain stem cells

10:15 - Coffee break  

10:45 - KEYNOTE LECTURE (Ronald McKay)

11:45 - POSTER AWARD

12:00 - Lunch break 

Session 4 - REPROGRAMMING AND STEM CELL PATHWAYS
Chair: Anthony Ho

13:15 - Marius Wernig
              Updates on induced neuronal cell reprogramming
13:45 - Jochen Utikal (short talk)
              Induced pluripotency and cancer cells
14:00 -  Varda Rotter
              The role of p53 in the life of stem cells

14:30 - Coffee break 

15:00 - Mariano Barbacid
              Cancer initiating cells in non small cell lung carcinoma
15:30 - Joachim Wittbrodt
              Exclusive multipotency in post-embryonic neural stem cells of the fish retina

16:00 - KEYNOTE LECTURE (Hans Clevers)
              Wnt signaling, Lgr5 stem cells and cancer

17:00 - Farewell reception