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Morgen, M. (First author) ; Steimbach, R. R. ; Geraldy, M. ; Hellweg, L. ; Sehr, P. ; Ridinger, J. ; Witt, O. ; Oehme, I. ; Herbst-Gervasoni, C. J. ; Osko, J. D. ; Porter, N. J. ; Christianson, D. W. ; Gunkel, N. ; Miller, A. (Last author) Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
ChemMedChem 15 (13 ), 1163 - 1174 (2020 ) [10.1002/cmdc.202000149 ] 2020
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Mayr, L. ; Guntner, A. S. ; Madlener, S. ; Schmook, M. T. ; Peyrl, A. ; Azizi, A. A. ; Dieckmann, K. ; Reisinger, D. ; Stepien, N. M. ; Schramm, K. ; Laemmerer, A. ; Jones, D. T. W. ; Ecker, J. ; Sahm, F. ; Milde, T. ; Pajtler, K. W. ; Blattner-Johnson, M. ; Strbac, M. ; Dorfer, C. ; Czech, T. ; Kirchhofer, D. ; Gabler, L. ; Berger, W. ; Haberler, C. ; Müllauer, L. ; Buchberger, W. ; Slavc, I. ; Lötsch-Gojo, D. ; Gojo, J. (Last author) Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma
Journal of Personalized Medicine 10 (4 ), 290 (2020 ) [10.3390/jpm10040290 ] 2020
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Nobre, L. ; Zapotocky, M. ; Ramaswamy, V. ; et al Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition.
JCO precision oncology 4 (4 ), 561 - 571 (2020 ) [10.1200/PO.19.00298 ] 2020
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Italiano, A. ; Nanda, S. ; Briggs, A. ; Garcia-Foncillas, J. ; Lassen, U. ; Vassal, G. ; Kummar, S. ; van Tilburg, C. M. ; Hong, D. S. ; Laetsch, T. W. ; Keating, K. ; Reeves, J. A. ; Fellous, M. ; Childs, B. H. ; Drilon, A. ; Hyman, D. M. Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis.
Cancers 12 (11 ), 3246 (2020 ) [10.3390/cancers12113246 ] 2020
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Wrobel, J. (First author) ; Najafi, S. ; Ayhan, S. ; Gatzweiler, C. ; Krunic, D. ; Ridinger, J. ; Milde, T. ; Westermann, F. ; Peterziel, H. ; Meder, B. ; Distel, M. ; Witt, O. ; Oehme, I. (Last author) Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts.
Pharmaceuticals 13 (11 ), 345 (2020 ) [10.3390/ph13110345 ] 2020
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Rusert, J. M. ; Juarez, E. F. ; Brabetz, S. ; Jensen, J. ; Garancher, A. ; Chau, L. Q. ; Tacheva-Grigorova, S. K. ; Wahab, S. ; Udaka, Y. T. ; Finlay, D. ; Seker-Cin, H. ; Reardon, B. ; Gröbner, S. ; Serrano, J. ; Ecker, J. ; Qi, L. ; Kogiso, M. ; Du, Y. ; Baxter, P. A. ; Henderson, J. J. ; Berens, M. E. ; Vuori, K. ; Milde, T. ; Cho, Y.-J. ; Li, X.-N. ; Olson, J. M. ; Reyes, I. ; Snuderl, M. ; Wong, T. C. ; Dimmock, D. P. ; Nahas, S. A. ; Malicki, D. ; Crawford, J. R. ; Levy, M. L. ; Van Allen, E. M. ; Pfister, S. ; Tamayo, P. ; Kool, M. ; Mesirov, J. P. ; Wechsler-Reya, R. J. Functional precision medicine identifies new therapeutic candidates for medulloblastoma.
Cancer research 80 (23 ), 5393-5407 (2020 ) [10.1158/0008-5472.CAN-20-1655 ] 2020
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Selt, F. (First author) ; van Tilburg, C. M. ; Bison, B. ; Sievers, P. ; Harting, I. ; Ecker, J. ; Pajtler, K. W. ; Sahm, F. ; Bahr, A. ; Simon, M. ; Jones, D. T. W. ; Well, L. ; Mautner, V.-F. ; Capper, D. ; Hernáiz Driever, P. ; Gnekow, A. ; Pfister, S. M. ; Witt, O. ; Milde, T. (Last author) Response to trametinib treatment in progressive pediatric low-grade glioma patients.
Journal of neuro-oncology 149 (3 ), 499-510 (2020 ) [10.1007/s11060-020-03640-3 ] 2020
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Traunwieser, T. ; Kandels, D. ; Pauls, F. ; Pietsch, T. ; Warmuth-Metz, M. ; Bison, B. ; Krauss, J. ; Kortmann, R.-D. ; Timmermann, B. ; Thomale, U.-W. ; Luettich, P. ; Neumann-Holbeck, A. ; Tischler, T. ; Hernáiz Driever, P. ; Witt, O. ; Gnekow, A. K. Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies.
Neuro-oncology advances 2 (1 ), vdaa094 (2020 ) [10.1093/noajnl/vdaa094 ] 2020
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Hassan, M. M. ; Israelian, J. ; Nawar, N. ; Ganda, G. ; Manaswiyoungkul, P. ; Raouf, Y. S. ; Armstrong, D. ; Sedighi, A. ; Olaoye, O. O. ; Erdogan, F. ; Cabral, A. D. ; Angeles, F. ; Altintas, R. ; de Araujo, E. D. ; Gunning, P. T. Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting
Journal of medicinal chemistry 63 (15 ), 8634 - 8648 (2020 ) [10.1021/acs.jmedchem.0c01025 ] 2020
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Gojo, J. ; Englinger, B. ; Jiang, L. ; Hübner, J. M. ; Shaw, M. L. ; Hack, O. A. ; Madlener, S. ; Kirchhofer, D. ; Liu, I. ; Pyrdol, J. ; Hovestadt, V. ; Mazzola, E. ; Mathewson, N. D. ; Trissal, M. ; Lötsch, D. ; Dorfer, C. ; Haberler, C. ; Halfmann, A. ; Mayr, L. ; Peyrl, A. ; Geyeregger, R. ; Schwalm, B. ; Mauermann, M. ; Pajtler, K. W. ; Milde, T. ; Shore, M. E. ; Geduldig, J. E. ; Pelton, K. ; Czech, T. ; Ashenberg, O. ; Wucherpfennig, K. W. ; Rozenblatt-Rosen, O. ; Alexandrescu, S. ; Ligon, K. L. ; Pfister, S. M. ; Regev, A. ; Slavc, I. ; Berger, W. ; Suvà, M. L. ; Kool, M. (Last author) ; Filbin, M. G. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.
Cancer cell 38 (1 ), 44 - 59.e9 (2020 ) [10.1016/j.ccell.2020.06.004 ] 2020
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Usta, D. (First author) ; Sigaud, R. ; Buhl, J. L. ; Selt, F. ; Marquardt, V. ; Pauck, D. ; Jansen, J. ; Pusch, S. ; Ecker, J. ; Hielscher, T. ; Vollmer, J. ; Sommerkamp, A. C. ; Rubner, T. ; Hargrave, D. ; van Tilburg, C. M. ; Pfister, S. M. ; Jones, D. T. W. ; Remke, M. ; Brummer, T. ; Witt, O. ; Milde, T. (Last author) A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells.
Molecular cancer therapeutics 19 (8 ), 1736-1750 (2020 ) [10.1158/1535-7163.MCT-19-1021 ] 2020
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Fangusaro, J. ; Witt, O. ; Hernáiz Driever, P. ; Bag, A. K. ; de Blank, P. ; Kadom, N. ; Kilburn, L. ; Lober, R. M. ; Robison, N. J. ; Fisher, M. J. ; Packer, R. J. ; Young Poussaint, T. ; Papusha, L. ; Avula, S. ; Brandes, A. A. ; Bouffet, E. ; Bowers, D. ; Artemov, A. ; Chintagumpala, M. ; Zurakowski, D. ; van den Bent, M. ; Bison, B. ; Yeom, K. W. ; Taal, W. ; Warren, K. E. Response assessment in paediatric low-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.
The lancet <London> / Oncology 21 (6 ), e305 - e316 (2020 ) [10.1016/S1470-2045(20)30064-4 ] 2020
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Kandels, D. ; Pietsch, T. ; Bison, B. ; Warmuth-Metz, M. ; Thomale, U.-W. ; Kortmann, R.-D. ; Timmermann, B. ; Driever, P. H. ; Witt, O. ; Schmidt, R. ; Gnekow, A. K. Loss of efficacy of subsequent non-surgical therapy after primary treatment failure in pediatric low-grade glioma patients - report from the German SIOP-LGG 2004 cohort.
International journal of cancer 147 (12 ), 3471-3489 (2020 ) [10.1002/ijc.33170 ] 2020
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van Tilburg, C. M. (First author) ; Witt, R. ; Heiss, M. ; Pajtler, K. W. ; Plass, C. ; Poschke, I. ; Platten, M. ; Harting, I. ; Sedlaczek, O. ; Freitag, A. ; Meyrath, D. ; Taylor, L. ; Balasubramanian, G. P. ; Jäger, N. ; Pfaff, E. ; Jones, B. C. ; Milde, T. ; Pfister, S. M. ; Jones, D. T. W. ; Kopp-Schneider, A. ; Witt, O. (Last author) INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies
BMC cancer 20 (1 ), 523 (2020 ) [10.1186/s12885-020-07008-8 ] 2020
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Krieger, T. G. (First author) ; Tirier, S. M. ; Park, J. ; Jechow, K. ; Eisemann, T. ; Peterziel, H. ; Angel, P. ; Eils, R. ; Conrad, C. (Last author) Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics.
Neuro-Oncology 22 (8 ), 1138-1149 (2020 ) [10.1093/neuonc/noaa091 ] 2020
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Waszak, S. ; Robinson, G. ; Gudenas, B. L. ; et al Germline Elongator mutations in Sonic Hedgehog medulloblastoma
Nature <London> 580 (7803 ), 396 - 401 (2020 ) [10.1038/s41586-020-2164-5 ] 2020
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Clarke, M. ; Mackay, A. ; Ismer, B. ; et al Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes.
Cancer discovery 10 (7 ), 942-963 (2020 ) [10.1158/2159-8290.CD-19-1030 ] 2020
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Hong, D. S. ; DuBois, S. G. ; Kummar, S. ; Farago, A. F. ; Albert, C. M. ; Rohrberg, K. S. ; van Tilburg, C. M. ; Nagasubramanian, R. ; Berlin, J. D. ; Federman, N. ; Mascarenhas, L. ; Geoerger, B. ; Dowlati, A. ; Pappo, A. S. ; Bielack, S. ; Doz, F. ; McDermott, R. ; Patel, J. D. ; Schilder, R. J. ; Tahara, M. ; Pfister, S. M. ; Witt, O. ; Ladanyi, M. ; Rudzinski, E. R. ; Nanda, S. ; Childs, B. H. ; Laetsch, T. W. ; Hyman, D. M. ; Drilon, A. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials.
The lancet <London> / Oncology Oncology 21 (4 ), 531-540 (2020 ) [10.1016/S1470-2045(19)30856-3 ] 2020
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Ameline, B. ; Saba, K. H. ; Kovac, M. ; Magnusson, L. ; Witt, O. ; Bielack, S. ; Nathrath, M. ; Nord, K. H. ; Baumhoer, D. NTRK fusions in osteosarcoma are rare and non-functional events.
The journal of pathology: clinical research 6 (2 ), 107-112 (2020 ) [10.1002/cjp2.158 ] 2020
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Pearson, A. D. J. ; Rossig, C. ; Lesa, G. ; Diede, S. J. ; Weiner, S. ; Anderson, J. ; Gray, J. ; Geoerger, B. ; Minard-Colin, V. ; Marshall, L. V. ; Smith, M. ; Sondel, P. ; Bajars, M. ; Baldazzi, C. ; Barry, E. ; Blackman, S. ; Blanc, P. ; Capdeville, R. ; Caron, H. ; Cole, P. D. ; Jiménez, J. C. ; Demolis, P. ; Donoghue, M. ; Elgadi, M. ; Gajewski, T. ; Galluzzo, S. ; Ilaria, R. ; Jenkner, A. ; Karres, D. ; Kieran, M. ; Ligas, F. ; Lowy, I. ; Meyers, M. ; Oprea, C. ; Peddareddigari, V. G. R. ; Sterba, J. ; Stockman, P. K. ; Suenaert, P. ; Tabori, U. ; van Tilburg, C. ; Yancey, T. ; Weigel, B. ; Norga, K. ; Reaman, G. ; Vassal, G. ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.
European journal of cancer 127 , 52 - 66 (2020 ) [10.1016/j.ejca.2019.12.029 ] 2020
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Deng, M. Y. (First author) ; Sill, M. ; Sturm, D. ; Stichel, D. ; Witt, H. ; Ecker, J. ; Wittmann, A. ; Schittenhelm, J. ; Ebinger, M. ; Schuhmann, M. U. ; Figarella-Branger, D. ; Aronica, E. ; Staszewski, O. ; Preusser, M. ; Haberler, C. ; Lauten, M. ; Schüller, U. ; Hartmann, C. ; Snuderl, M. ; Dunham, C. ; Jabado, N. ; Wesseling, P. ; Deckert, M. ; Keyvani, K. ; Gottardo, N. ; Giangaspero, F. ; von Hoff, K. ; Ellison, D. W. ; Pietsch, T. ; Herold Mende, C. ; Milde, T. ; Witt, O. ; Kool, M. ; Korshunov, A. ; Wick, W. ; von Deimling, A. ; Pfister, S. M. ; Jones, D. T. W. ; Sahm, F. (Last author) Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14.
Neuropathology & applied neurobiology 46 (5 ), 422-430 (2020 ) [10.1111/nan.12590 ] 2020
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Holland-Letz, T. (First author) ; Leibner, A. ; Kopp-Schneider, A. (Last author) Modeling dose-response functions for combination treatments with log-logistic or Weibull functions.
Archives of toxicology 94 (1 ), 197-204 (2020 ) [10.1007/s00204-019-02631-2 ] 2020
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Holzapfel, J. ; Kandels, D. ; Schmidt, R. ; Pietsch, T. ; Warmuth-Metz, M. ; Bison, B. ; Krauss, J. ; Kortmann, R.-D. ; Timmermann, B. ; Thomale, U.-W. ; Albert, M. H. ; Hernáiz Driever, P. ; Witt, O. ; Gnekow, A. K. Favorable prognosis in pediatric brainstem low-grade glioma - report from the German SIOP-LGG 2004 cohort.
International journal of cancer 146 (12 ), 3385-3396 (2020 ) [10.1002/ijc.32734 ] 2020
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